HOWARU® HN019™ HOWARU® HN019™ Bifidobacterium lactis HN019™ Image credits: © IFF, Finland, 2021 (FESEM imaging VTT) HOWARU® Bifidobacterium lactis HN019™ has been consumed in dairy foods for decades and is well-studied for its probiotic properties in more than 180 scientific publications. It has been demonstrated to tolerate acidic conditions and shown to survive passage through the human intestine.¹⁻³ Product Information: 81 preclinical study publications ~68 clinical trial publications Health Benefits: DigestiveEarly Life DevelopmentImmuneOral HN019™ BLENDS Learn more about IFF Health Sciences’ HN019™ blends. HOWARU® GI Complete HOWARU® Kids Digestive Health HOWARU® Protect 55+ HOWARU® Smile HOWARU® Transit HN019™ CLINICAL STUDIES & PUBLICATIONS Mechanistic data suggests HN019™ may influence colonic motility, and multiple clinical trials with HN019™ alone or in combination with prebiotics or other probiotic strains have resulted in increased gut transit in persons with less frequent bowel movements positioned for adults as HOWARU® Transit and for kids as HOWARU® Kids Digestive Health.⁴⁻⁶ HOWARU® Protect 55+ has also been shown to modulate immune function, particularly enhancing cellular immune activity in aging persons.⁷ It also offers oral health benefits as HOWARU® Smile offering a natural, alternative way to support healthy gum tissue and promote an overall healthy smile. Health Benefit Areas Each strain’s health benefits are supported by recommended daily doses and peer-reviewed clinical studies. Click on a Health Benefit to see more studies and learn more. Digestive Health Supporting Daily Dose: 2B and 17B CFU HN019™ Study Reference: Waller PA, et al. Scand J Gastroenterol. 2011;46(9):1057-1064. Supporting Daily Dose: 5B CFU HN019™ Study Reference: Hemalatha R, et al. EJNF. 2014; 4(4):325-341. LEARN MORE Immune Health Supporting Daily Dose: 5B CFU minimum HN019™ Study Reference: Miller LE, et al. Nutrients. 2017; 9(3):191. LEARN MORE Oral Health Supporting Daily Dose: 2B CFU HN019™ Study Reference: Invernici M, et al. J Clinical Periodontology. 2018;45(10):1198-1210. Study Reference: de Almeida Silva Levi YL, et al. Clin Oral Investig. 2022;27(1):387-398. LEARN MORE References: 1. Gopal PK et al.; Nutrition Research. 2003; 2. Prasad J et al.; Intl Dairy J. 2013; 3. Wickens K et al.; J Allergy Clinical Immunology. 2008; 4. Dalziel Je et al.; Frontiers in Neuroscience. 2017; 5. Ibarra A et al.; Gut Microbes. 2017; 6. Waller PA et al.; Scandinavian J Gastroenterology. 2011; 7. Miller LE et al.; Nutrients. 2017.